The Microbiological Background of Medication-Related Osteonecrosis of the Jaw (MRONJ): Clinical Evidence Based on Traditional Culture and Molecular Biological Detection Methods.

While existing evidence confirms that the characteristics (indication, type, dose, and mode of administration) of the antiresorptive treatment prescribed and the underlying characteristics of the patient are definitely significant, the results from our current study show that alterations in the oral microbiome—with Actinomyces and related species being the most relevant—play a key role in the development of MRONJ, which without a doubt, interact with other factors described.

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