Therapeutic Actions of Hepatocyte Extracellular Vesicles in a Murine Model of Diet-Induced Steatohepatitis with Fibrosis.

Whereas EVs at the 4 × 10 8 particle dose once per week at week 4 or the particle doses of 2 × 10 9 or 4 × 10 8 at, respectively, once or three times per week at Week 8 were not effective in reducing collagen ( Figure 2 C), these data points appear to be spurious outliers; all other EVs doses were highly significant in their ability to suppress collagen deposition.

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