Induction of PD-1 and CD44 in CD4<sup>+</sup> T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway.

J Virol · 2025 · PMC11852895 · PMID 39745465

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may be significantno p-value reported

In conclusion, we provided evidence that SD-EV-CD4 carrying PD-1 and CD44, when interacting with EC, significantly affected endothelial cell properties and may be significant in dengue-mediated endothelial dysfunction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Induction of PD-1 and CD44 in CD4&lt;sup&gt;+&lt;/sup&gt; T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway.

The sentences

Induction of PD-1 and CD44 in CD4<sup>+</sup> T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway.