PBMC-derived 4X also displayed a slight trend toward increased sensitivity (1- to 2-fold) to a variety of bNAbs, with the notable exception of VRC-CH31, to which it was 3-fold more resistant ( Figures S3 and S4 ).
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In vivo evolution of env in SHIV-AD8<sub>EO</sub>-infected rhesus macaques after AAV-vectored delivery of eCD4-Ig.
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