Barely Significant
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Extrapolation of PBBs Environmental Transformation Mechanisms and Toxicity Risks of Byproducts.

Int J Mol Sci · 2025 · PMC11855703 · PMID 40004216

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an increasing trendno p-value reported
The combustion oxidation products of PBBs showed an increasing trend in toxicity; for instance, products after combustion of PBB-4 and PBB-29 increased from toxic to highly toxic, indicating a significant biological toxicity that warrants attention, consistent with the high mutagenic and carcinogenic risks associated with the combustion oxidation products of PBBs.

also in 63,971 other papers

a decreasing trendno p-value reported
This suggests a higher acute toxicity risk for these substitutes in rats, whereas D1 showed a decreasing trend in the acute toxicity risk.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.