Adaptive Proteomic Changes in Protein Metabolism and Mitochondrial Alterations Associated with Resistance to Trastuzumab and Pertuzumab Therapy in HER2-Positive Breast Cancer.

In particular, the analysis of the SLC2A1 and PPIG proteins ( Figure 11 A,B) demonstrated that the difference in RFS between the high- and low-expression groups was statistically highly significant, whereby patients with a low level of expression were at approximately half the risk of recurrence compared with high-expression patients.

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