Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export.

Dual metabolic blockade, when combined with DOX, led to highly significant increases in apoptosis in vitro ( Fig. 2 C ) and in vivo in HCC1806 tumors ( Fig. 5 C-D ), likely mediated by disrupted cellular redox balance due to depletion of GSH.

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