highly significantP = 5.0 × 10 −23
Previous reports have implicated deleterious coding variants in IFIH1 , the third member of the RLR family, as conferring protection against psoriasis 8 , 71 and psoriatic arthritis 72 ; the protective IFIH1 variants rs35667974 and rs1990760 are both highly significant in the current meta-analysis ( P = 5.0 × 10 −23 and 7.0 × 10 −50 , respectively) but not prioritised in credible sets due to insufficient effective sample size and the presence of a more strongly associated intronic variant (rs2111485), respectively.