In silico discovery of a novel potential allosteric PI3Kα inhibitor incorporating 2-oxopropyl urea targeting head and neck squamous cell carcinoma.

BMC Chem · 2025 · PMC11871742 · PMID 40022235

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a decreasing trendno p-value reported

7 C, the SASA values of PI3Kα in PI3Kα- STX-478 / J-53 complexes showed a decreasing trend during simulation processes.

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