Integration of Single Cell and Bulk RNA-Sequencing Reveals Key Genes and Immune Cell Infiltration to Construct a Predictive Model and Identify Drug Targets in Endometriosis.

In our current study, according to CIBERSORT and ssGSEA analysis, we observed a higher abundance of CD8+ T cells and monocytes and an increasing trend in M2 macrophages in patients with endometriosis compared to the control group, which aligns with previous research findings. 56 , 57 In 2021, Ma J et al performed scRNA-seq on endometrial tissue from three healthy controls and three endometriosis patients. 57 The study identified significant differences in cell subtypes and gene expression between the eutopic endometrium of endometriosis patients and healthy controls, with monocytes notably more prevalent in the eutopic endometrium of endometriosis.

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