The recent trend of twin epidemic in the United States: a 10-year longitudinal cohort study of co-prescriptions of opioids and stimulants.

Lancet Reg Health Am · 2025 · PMC11876894 · PMID 40040818

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an increasing trendno p-value reported

Added value of this study Previous studies have suggested an increasing trend of co-use of these two types of drugs in patient populations, while no large-scale studies have confirmed this pattern on a national level.

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