Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus.

Invest Ophthalmol Vis Sci · 2025 · PMC11878249 · PMID 39992672

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11 , 12 A decreasing trend in the collagen crosslinking enzyme LOX levels and enzymatic activity in tear fluids were observed in higher grades of KC. 13 – 16 Similarly, by modulating collagen degradation proteolytic enzymes like collagenase, gelatinase, peptidase, and heparinase play a major role in extra-cellular matrix (ECM) remodeling.

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