Integrated UPLC-ESI-MS/MS, network pharmacology, and transcriptomics to reveal the material basis and mechanism of Schisandra chinensis Fruit Mixture against diabetic nephropathy.

Front Immunol · 2024 · PMC11879837 · PMID 40046619

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a decreasing trendno p-value reported

IF analysis revealed significant expression of p-AKT and p-mTOR in the glomeruli and tubulointerstitium of the DN group, while a decreasing trend in p-AKT and p-mTOR expression was observed in the rats in the SM-M, and SM-H groups ( Figures 7C–E ).

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