Neurophysiological Treatment Effects of Mesdopetam, Pimavanserin and Amantadine in a Rodent Model of Levodopa-Induced Dyskinesia.

In this late phase, mesdopetam (3 and 10 mg/kg) and amantadine showed a highly significant antidyskinetic effect compared to vehicle treatment (Figure 2B right panel; p < 0.001; GLME and Tukey‐HSD test; it should be noted that in the current design, amantadine was injected 30 min earlier than mesdopetam, possibly explaining the temporal difference observed).

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