Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer's disease.

We found a marginally significant interaction between HT and baseline age such that older HT users exhibited marginally faster rates of neocortical Aβ accumulation relative to older non-users [Aβ = −0.07; 95% confidence interval (CI), −0.01 to 0.15; P = 0.051; Fig. 1 and Table 2 ], adjusting for baseline BMI × time.

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