INDUCTION OF EARLY PULMONARY SENESCENCE IN EXPERIMENTAL SEPSIS.

In BALF, we detected a highly significant raise of the concentration of CXCL1, a chemoattractant especially for neutrophils ( 22 ), in septic versus sham conditions ( P ≤ 0.0001; Fig. 2 C).

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Furthermore, the expression of lamin B1, a nuclear protein that is known to be reduced in cellular senescence ( 26 ), also demonstrated a decreasing trend in the murine cohort 24 h after CLP (Fig. 4 F).

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