Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion.

A decreasing trend was observed for 2% Na citrate and 0.18% EDTA, though not significant compared to the control (Fig. 5 C).

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Also, an increasing trend in platelet aggregation was observed at 13 mg/dL Ca 2+ and 16 mg/dL Ca 2+ , though not statistically significant (Fig. 4 C,D).

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Treating MDA-MB-231 with 1% Na citrate, 0.18% EDTA, and 18 mg/dL Ca 2+ did not significantly modulate MDA-MB-231 invasion, but a downward trend was observed for the chelation conditions while a positive trend was observed with calcium addition (Fig. 7 A).

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