Increased PCSK9 associated with cIMT in AS: A useful marker for subclinical atherosclerosis in patients with ankylosing spondylitis.

dition, PCSK9 induces atherosclerosis by increasing oxidative stress and cytokine release regardless of LDL levels.[ 17 ] In the literature, there is strong evidence that a high LDL level is related to the etiology of AS, as well as atherosclerosis.[ 18 ] Therefore, PCSK9 levels in patients with AS may be significant for both atherosclerosis and the etiology of the disease.

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There was also a highly significant correlation between cIMT and disease activity (BASFI and BASDAI), but not between the PCSK9 and BASFI and BASDAI.

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