Dysregulation of muscle cholesterol transport in amyotrophic lateral sclerosis.

Brain · 2025 · PMC11884649 · PMID 39197036

Europe PMC DOI

hedged sentence

0.0519

closest p · 1.0× alpha

0.0519

boldest claim

The sentences

almost reached significanceP = 0.0519so close (0.05 < p ≤ 0.1)

In ALS patients, we found a positive correlation between SDHB mRNA level in muscle and functional status (evaluated by the ALSFRS-R score), which almost reached significance ( r = 0.7186, P = 0.0519), whereas SDHB levels were unchanged overall when compared to controls ( Fig. 6F and G ).

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