Based on Bugbase phenotypic predictions, anaerobic and Gram-positive bacteria in APAP group exhibited a decreasing trend, while BSL-pretreatment can reverse this situation, which was consistent with findings observed in our DILI patients (Fig. 1 F, 4 D).
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Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway.
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