HIF has been shown to increase TIBC and reduce hepcidin and TSAT in dialysis independent CKD [ 42 – 44 ], in our study, due to the combination with PIC, the TIBC level of the roxadustat treatment group was higher than that of the CKD only group, but there was no significant clinical significance, and the TSAT was not significantly significant among all groups, suggesting that roxadustat can increase iron utilization and decrease iron storage, and additional iron therapy is required.
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Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats.
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