Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome.

Ital J Pediatr · 2025 · PMC11887386 · PMID 40055727

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0.0830

closest p · 1.7× alpha

0.0830

boldest claim

The sentences

marginally significantp = 0.083so close (0.05 < p ≤ 0.1)

Additionally, it was determined that the mediation effect of the GC response on the Ac-H3 expression was marginally significant ( p = 0.083) and accounted for approximately 62% of the total effect relative to its indirect effect, suggesting that the GC response may influence the Ac-H3 expression indirectly through altering the expression of NF-κB.

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