Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.

In our study, we found that GSCs are more sensitive (by around 10‐fold) to malformin C than the cell lines investigated by Wang et al., and the tumor inhibitory effect of malformin C on GSCs in vivo was highly significant, which suggests that the compound could still be an attractive option as a therapy for glioblastoma.

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