Unsupervised Learning-Derived Complex Metabolic Signatures Refine Cardiometabolic Risk.

JACC Adv · 2025 · PMC11891690 · PMID 39983615

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closest p · 0.8× alpha

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boldest claim

The sentences

borderline significantP = 4.1 × 10 −2actually significant

ML-HDL appeared to be a concordant protective factor against cardiometabolic diseases (Cox HR IHD = 0.85 [95% CI: 0.83-0.87]; HR hyperlipemia = 0.88 [95% CI: 0.86-0.90]; HR hypertension = 0.90 [95% CI: 0.89-0.92]; HR T2D = 0.61 [95% CI: 0.59-0.63]), with a borderline significant causal effect observed between ML-HDL and reduced IHD risk (IVW β = −0.08, P = 4.1 × 10 −2 ).

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