Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity.

Circulation · 2025 · PMC11893002 · PMID 39556714

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highly significantno p-value reported

What Are Clinical Implications? The SUMMIT trial demonstrated that in patients with heart failure with preserved ejection fraction and obesity, tirzepatide treatment produces a consistent and highly significant beneficial effect on multiple orthogonal metrics of disease severity at all measured time points.

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