Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease.

Highly significant differential abundance of chain length 18 CLs was found in C3H nDNA :C3H mtDNA WT plasma and C57 nDNA :C3H mtDNA MNX skeletal muscle and plasma, which may indicate C3H mtDNA -specific regulation of these mitochondrial glycerophospholipids. ‘Fructose and mannose metabolism’ (mmu00051; P -value = 4.63 × 10 −3 ), ‘Steroid biosynthesis’ (mmu00100; P -value = 4.77 × 10 −3 ), and ‘Arginine biosynthesis’ (mmu00220; P -value = 1.61 × 10 −2 ) were notably significantly enriched ( Fig. 6 B). 3.3.11.

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