Poly-γ-glutamic acid alleviates slow transit constipation by regulating aquaporin and gut microbes.

Sci Rep · 2025 · PMC11893738 · PMID 40065004

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2 E-G, the mRNA expression of Claudin-1 , Occludin , and ZO-1 in the colon of LOP group showed a decreasing trend compared with those in CK group ( p > 0.05). γ -PGAM treatment enhanced the expression of Claudin-1 , Occludin , and ZO-1 genes at the mRNA levels compared with the LOP group, albeit there was an upward trend observed in γ-PGAL and γ-PGAH groups( p < 0.05 or < 0.01).

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