SLAMF7 (CD319) on activated CD8⁺ T cells transduces environmental cues to initiate cytotoxic effector cell responses.

Next, we applied this mode of SLAMF7-activation to antigen-presenting spheres and found that SLAMF7-signals facilitated the formation of stable T-cell populations also in response to antigen-specific activation that was highly significant even in responses towards the lowest affinity OVA peptide SIIVFEKL (V4) (Fig. 3F ).

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