Activation of ASIC3/ERK pathway by paeoniflorin improves intestinal fluid metabolism and visceral sensitivity in slow transit constipated rats.

As shown in Figure 7A–D , amiloride‐treated rats showed a decreasing trend or significant decrease in AWR score, an increasing trend in pain threshold, a significant decline in serum 5‐HT, and an increasing trend in serum VIP compared with the PF group, whereas there were no significant differences compared with the STC group in any of the indexes except for the AWR score at 40 mmHg.

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While the number of goblet cells in the amiloride group showed a decreasing trend compared to the PF group, it is suggested that the effect of PF on increasing STC colonic goblet cells was partially attenuated by amiloride.

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