Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment.

However, like primary infection, the proportion of MHV‐specific S‐tet + CD44 hi CD8 + cells was significantly reduced in aged animals compared to adult controls following MHV‐JHM rechallenge, though the total numbers of cells was not quite statistically significant (Figure 4e,f ).

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