LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.

By integrating the top 10 enriched KEGG pathways of DEGs from each comparison, PI3K-Akt pathway emerged as a highly significant signaling pathways in ZBTB20-associated mechanisms, ranking high in WTvsWT_IL-1β group while not present in the KO_IL-1βvsKO group, with overlapping appearance in both KOvsWT and KO_IL-1βvsWT_IL-1β groups (Fig. 3b ).

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