Hepatic Deletion of Carbohydrate Response Element Binding Protein Impairs Hepatocarcinogenesis in a High-Fat Diet-Induced Mouse Model.

As expected, we observed that mice fed with long-term HFD exhibited significantly higher hepatic triglyceride storage, whereas the control diet did not induce triglyceride storage in both WT and L-ChREBP KO mice, resulting in a highly significant difference between the control and HFD groups ( p < 0.05) in Figure 2 E.

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