The Combined Assessment of CTC and <i>ESR1</i> Status in Liquid Biopsy Samples Enhances the Clinical Value of Prediction in Metastatic Breast Cancer.

The borderline significance of our analysis may result from the relative heterogeneity of our group of patients in terms of the observation period, so in some patients, resistance-conferring mutations may not be present because there was not enough time for the evolution of the resistance.

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However, our results on the impact of cfDNA mutations were on the borderline of significance ( ESR1 ) or insignificant ( PIK3CA ) in Kaplan–Meier survival analysis.

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