Gut microbiota is associated with persistence of longer-term BNT162b2 vaccine immunogenicity.

Front Immunol · 2025 · PMC11903479 · PMID 40083550

Europe PMC DOI

hedged sentences

0.0910

closest p · 1.8× alpha

0.0910

boldest claim

The sentences

of borderline significancep=0.091so close (0.05 < p ≤ 0.1)

For SCFAs, butyrate was significantly associated with extreme high vaccine response (aOR:10.00, 95% CI:1.81-107.2; p=0.025), while propionate was of borderline significance (aOR:1.33, 95% CI: 0.97-1.92; p=0.091) and acetate did not show significant association (aOR:1.01, 95% CI:0.99-1.02; p=0.368).

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a decreasing trendno p-value reported

excrementihominis and DM status, and taking high abundance-non DM as reference, there was a decreasing trend of NAb level at day 180 (p-trend=0.022, Supplementary Table 4 ).

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borderline significantno p-value reported

A two-sided p-value ≤0.05 was considered as statistically significant, while a p-value ≤ 0.1 was considered borderline significant.

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