Systematic evaluation of the evidence base on methyl <i>tert</i>-butyl ether supporting a lack of concern for carcinogenic hazard in humans based on animal cancer studies and mechanistic data.

Curr Res Toxicol · 2025 · PMC11903976 · PMID 40084233

Europe PMC DOI

hedged sentence

0.1810

closest p · 3.6× alpha

0.1810

boldest claim

The sentences

a statistical trendp < 0.181not close (p > 0.1)

A statistically increased astrocytoma incidence was reported at 7.5 mg/mL MTBE (calculated dose: ∼333 mg/kg-bw/day) when assessed using a statistical trend test (Cochran), but not when using a pairwise comparison (Fisher’s exact test p < 0.181).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Systematic evaluation of the evidence base on methyl &lt;i&gt;tert&lt;/i&gt;-butyl ether supporting a lack of concern for carcinogenic hazard in humans based on animal cancer studies and mechanistic data.

The sentences

Systematic evaluation of the evidence base on methyl <i>tert</i>-butyl ether supporting a lack of concern for carcinogenic hazard in humans based on animal cancer studies and mechanistic data.