Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers.

Front Immunol · 2025 · PMC11907206 · PMID 40093011

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closest p · 1.2× alpha

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boldest claim

The sentences

nearly reached significancep = 0.06so close (0.05 < p ≤ 0.1)

Lastly, in the differential between ANA- SLE and AHV ( Figure 2F ), TC4d (AUC: 0.75) significantly outperformed anti-Smith (0.42, p < 0.01) and nearly reached significance for superior performance against anti-dsDNA (0.51, p = 0.06) and C3 (0.50, p = 0.05).

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