Regarding other clinical outcomes, despite the potential influence of various factors, the higher hemoglobin levels and reduced diuresis observed 48 h following surgery as well as a weak trend towards less subdural drainage (medians of 206 and 308 ml) in isotonic balanced patients, might indicate a lower accumulation of intravascular fluids and brain edema associated with intraoperative use of isotonic balanced maintenance fluid compared to hypotonic fluid.
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Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.
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