A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarate.

BMC Cancer · 2025 · PMC11909988 · PMID 40087637

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highly significantno p-value reported

We found a highly significant increase in the mean FRET ratio upon analyzing IDH1 mutant versus IDH1 wildtype samples, with average FRET ratios of 2.05 ± 0.14 and 1.54 ± 0.05, respectively (Fig. 7 b).

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