Magnetic bead-sensitized optoporation coupled with antibodies-based activation for mRNA CAR-T cell manufacturing.

This result was consistent with the cytokine secretion profile observed after 72 h of co-culture with target cells, in which CAR-T cells generated via electroporation (CAR EP) exhibited significantly higher IL-2 release compared with optoporated CAR-T cells (CAR OP), and an overall trend of CAR EP cells to secrete higher levels of cytokines, particularly IL-6, TNF-α, granzyme B, and granzyme A ( Figure 5 F).

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