Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

The combined clinical data of cohort-1 ( 47 ) and cohort-2 ( Figure 6B ) suggest that DEX prophylaxis may mildly mitigate acute high altitude PH (HAPH), a type of hypoxic PH, as the DEX-p group at HA had a nonsignificant trend toward lower RVSP (post hoc P values when accounting for multiple comparisons: P = 0.175).

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We observed that the deletion of a single copy of CCL2 resulted in a trend toward reduced RVSP, whereas the deletion of both CCL2 copies led to a significant reduction in RVSP, along with a pronounced trend toward reduced RVH compared with mice with either 1 copy deleted or both copies intact under hypoxia ( Figure 5, F and G ).

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