Circulating Inflammatory Factors and Bidirectional Mendelian Randomization Analysis in Patients with Kawasaki Disease.

Vasc Health Risk Manag · 2025 · PMC11910938 · PMID 40092571

Europe PMC DOI

hedged sentences

0.0951

closest p · 1.9× alpha

0.0951

boldest claim

The sentences

borderline significanceP=0.0951so close (0.05 < p ≤ 0.1)

Among these 41 circulating inflammatory factors, MR‒Egger analysis revealed four inflammatory factors with borderline significance: B_NGF [OR=1.0242, 95% CI: 0.9960–1.0532; P=0.0951]; EOTAXIN [OR=1.0191, 95% CI: 1.0001–1.0385; P= 0.0511] (with significant horizontal pleiotropy, pval=0.0433); HGF [OR=1.0165, 95% CI: 0.9972–1.0361; P=0.0965]; and IL_12_P70 [OR=1.0160, 95% CI: 0.9978–1.0346; P=0.0880].

also in 7,017 other papers

marginally significantno p-value reported

24 There may be complex interactions between IL-2 and IL-8 and other marginally significant factors.

also in 26,082 other papers

borderline significantno p-value reported

Borderline significant associations were observed for factors such as B_NGF, EOTAXIN, HGF, and IL_12_P70 in MR‒Egger and weighted median analyses.

also in 11,409 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.