Scutellarin ameliorates ischemia/reperfusion-mediated endothelial dysfunction by upregulating cathepsin D expression to rescue autophagy-lysosomal function.

Front Pharmacol · 2025 · PMC11911473 · PMID 40098620

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an increasing trendno p-value reported

Our data showed that LAMP1 displayed an increasing trend both in vitro and in vivo in the endothelial dysfunction model, which was consistent with that of LC3II/I and P62 levels, suggesting a potential connection with the buildup of autolysosomes.

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