Recessive genetic contribution to congenital heart disease in 5,424 probands.

Proc Natl Acad Sci U S A · 2025 · PMC11912448 · PMID 40030011

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closest p · 0.0× alpha

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highly significantP = 1.5 × 10 −10actually significant

From the genome-wide binomial test, C1orf127 showed highly significant enrichment for damaging RGs (enrichment = 176.8, P = 1.5 × 10 −10 ; Fig. 1 A ) and a greater enrichment for LoF RGs (enrichment = 392.4, P = 2.6 × 10 −12 ; SI Appendix , Fig.

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