Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda.

Cell Rep · 2025 · PMC11913526 · PMID 39893635

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highly significantno p-value reported

Additionally, Gene Ontology (GO) pathway analysis ( Figure 5F ; Tables S1B and S1C ) revealed highly significant association of both clusters with immune pathways (e.g., innate immune response).

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a decreasing trendno p-value reported

We observed a decreasing trend of Ifit1 transcripts in the colon of Ifnlr1 -deficient mice ( Ifnlr1 −/− Ifnar1 +/− and Ifnlr1 −/− Ifnar1 −/− ) in comparison to Ifnlr1 -sufficient mice ( Ifnlr1 +/− Ifnar1 −/− and Ifnlr1 +/− Ifnar1 +/− ), suggesting that homeostatic IFN-λ specifically contributes to homeostatic Ifit1 expression in the neonatal colon.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.