MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.

Nat Commun · 2025 · PMC11914251 · PMID 40097443

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highly significantno p-value reported

While NET39 depletion alone caused only a subtle shift of the MyoD1 locus towards a more central position within the nucleus, additional depletion of Tmem38a induced a statistically highly significant change in the localization of MyoD1 towards the nuclear interior, which was further enhanced upon deletion of WFS1 (Fig. 4b , left panel).

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