Furthermore, the percentage of thick collagen fibers (red) showed an increasing trend after culture in all three tOVA donors (2.8 ± 0.5% at D0 and 6.9 ± 0.7% at D8 in tOVA70; 10.5 ± 1.5% at D0 and 17.0 ± 5.9% at D8 in tOVA23; and 7.3 ± 2.4% at D0 and 12.9 ± 7.4% at D8 in tOVA20).
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<i>Ex vivo</i> removal of pro-fibrotic collagen and rescue of metabolic function in human ovarian fibrosis.
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