All-in-one CRISPR/Cas-engineered glucocorticoid-receptor knock-out EBV-gp350-CAR knock-in T cells are potent and resistant to dexamethasone.

Within the analysis of cell culture supernatants, a pattern of T h1 as well as T h2 -cytokines and markers (granzyme A, granzyme B, IFNγ, TNFα, granulysin, perforin, sFas, sFasL, IL-2, IL-6, IL-17, IL-10 and IL-4) showed highly significant correlation between the CAR KI and CAR KI GR KO cells upon HEK gp350 stimulation (r = 0.98, p < 0.0001, Fig. 3 A).

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