Respiratory tract lining fluid copper content contributes to pulmonary oxidative stress in patients with systemic sclerosis.

Earlier studies have examined the procedural factors that may be significant in causing variability in the concentration of lavage components, such as dwell time, the volume of saline instilled, the number of aliquots and the inclusion or exclusion of the first lavage instillment 26 .

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This borderline significance may be attributable to the limited sample size, suggesting that a larger study could reveal a clearer distinction.

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