Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice.

Int J Pharm X · 2025 · PMC11925117 · PMID 40115963

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a possible trendno p-value reported

Fluorescence spectroscopy of tissue lysates from PEG-DMG-LNP-treated animals revealed no statistically significant differences in tumor accumulation but showed a possible trend towards more tumor accumulation when animals were pre-treated with liposomes for both Cy5.5 (control 3.17 % vs liposomes 5.92 %) ( Fig. 3 f) and Cy7 (control 3.61 % vs liposomes 7.04 %) ( Fig. 3 g).

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