Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests.

NPJ Vaccines · 2025 · PMC11928608 · PMID 40118915

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a decreasing trendno p-value reported

5 , after immunization with vaccines subjected to different degrees of destruction, the neutralizing antibody titers in mouse sera showed a decreasing trend for vaccines against HPV6, 11, 16, and 18; The in vitro relative potency exhibited a decreasing trend for vaccines against HPV6, 11, 16, and 18 after different degrees of destruction.

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